Now, four-in-one pill to treat high blood pressure
An article published in the Feb Issue of the Lancet describes a randomised, placebo-controlled, double-blind, crossover trial conducted in Australia with a quadpill—a single capsule containing 4 blood pressure-lowering drugs each at quarter-dose (irbesartan 37·5 mg, amlodipine 1·25 mg, hydrochlorothiazide 6·25 mg, and atenolol 12·5 mg) vs placebo. Blood pressure dropped to normal levels for every single patient within 4 weeks.


The findings of the small trial in the context of previous randomised evidence suggest that the benefits of quarter-dose therapy could be additive across classes and might confer a clinically important reduction in blood pressure. Further examination of the quadpill concept is needed to investigate effectiveness against usual treatment options and longer term tolerability.
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