OCTA reveals enlarged foveal avascular zone in preclinical A
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Investigators longitudinally examined long-term alterations in the foveal avascular zone (FAZ) in patients with preclinical Alzheimer disease.

The authors conducted a 3-year prospective Optical coherence tomography angiography (OCTA) study of 20 cognitively normal patients, 9 of which had positive biomarkers of preclinical Alzheimer disease (positive amyloid PET scan and/or cerebrospinal fluid analysis), while 11 were biomarker negative.

Results:
--At 3-year follow-up, only 1 patient developed mild dementia while the rest of the subjects had no detectable cognitive changes.

--As found in the original baseline study, the FAZ remained enlarged in biomarker-positive eyes compared with biomarker-negative eyes (0.368 vs 0.272 mm2).

--However, there was no significant change in the FAZ between groups over the study period.

--Additionally, the authors did not observe differences in any other structural measurements of the retina, including the retinal nerve fiber or ganglion cell layers.

The FAZ remains enlarged in patients with preclinical Alzheimer's disease, meaning that OCTA can be used to better classify patients at risk of developing the disease. However, the rate of improvement is slow, and no discernible changes were seen in a cohort of patients with mostly no cognitive deficits over a three-year period. These results back up the theory that the preclinical stage of Alzheimer's disease will last a long time.

Source: https://www.aao.org/editors-choice/octa-reveals-enlarged-foveal-avascular-zone-in-pre-2
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