ORTHO - REVIEW 1.Rice grain sequestrum is seen in tuberculo
Dr. Ajay Gupta
ORTHO - REVIEW

1.Rice grain sequestrum is seen in tuberculosis

2. Ring sequestrum around amputation stump . Also seen around pin tracks of external fixators

3. Tubular sequestrum in hematogenous osteomyelitis

4. MESS (mangled extremity severity score ) evaluates chances of amputation in traumatic limb.

5. Gustilo and anderson classification : classification of open fracture

6. Major mineral of bone matrix is calcium hydroxyapatite

7. First stage of fracture healing is hematoma formation , last stage is stage of remodelling

8. Criteria for predicting risk of pathological fracture : MIRELS CRITERIA



PHARMA - REVIEW

1. DOC for choriocarcinoma : methotrexate

2. DOC for pancreatic cancer : gemcitabine

3. DOC for Chronic lymphocytic leukemia : fludarabine

4. Alkylating agents are used for chronic leukemia whereas antimetabolites are commonly used for acute leukemias

5. Marrow sparing cytotoxic drugs are vincristine , bleomycin , L - aspariginase

6. Distinctive toxicity of bleomycin is pulmonary fibrosis

7. Earliest indicator of bleomycin induced pulmonary fibrosis is decrease in DLCO

8. Doc for wegener granulomatosis : cyclophosphamide

9. Hemorrhagic cystitis is the side effect of using ifosfamide and cyclophosphamide. Metabolite responsible for it is ACROLEIN.
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