Obesity Is Deadlier in Men With COVID-19 Than in Women
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The association between obesity and poor outcomes in COVID-19 are worse in men than women, with increased rates of in-hospital death, shows the largest study to date exploring the different impact of obesity between the sexes on COVID-19.

It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation.

This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35–39.9 kg/m2 and BMI more than 40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI more than 40 kg/m2 was found significant in the subgroup of women.

No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.

Source: https://link.springer.com/article/10.1007/s10096-021-04260-z
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