Obesity associated metabolites in relation to type 2 diabete
Serum based nuclear magnetic resonance imaging metabolomics data was generated from two South Asians population based prospective cohorts from Karachi, Pakistan: CARRS1 (N=4,017) and CARRS2 (N=4,802). Participants in both cohorts were followed-up for 5-years and incident diabetes was ascertained. A nested case-control study approach was developed to select participants from CARRS1 (Ncases=197 and Nc and CARRS2 (Ncases=194 and Nc respectively. First, we investigated the association of 224 metabolites with general obesity based on BMI, and central obesity based upon waist-hip ratio, and then the top hit obesity-associated metabolites were studied in association with incident T2DM.

In a combined sample of CARRS1 and CARRS2, out of 224 metabolites 12 were associated with general obesity and among those 1 was associated with incident T2DM. Fifteen out of 224 metabolites were associated with central obesity and among those 10 were associated with incident T2DM. Total cholesterol in HDL was associated with reduced T2DM risk (OR, 0.68; 95% CI 0.53, 0.86; p-value=1.2E-03) while cholesterol esters in large VLDL particle was associated with higher T2DM risk (OR, 1.90; 95% CI 1.40, 2.58; p-value=3.5E-05).

Total cholesterol in HDL and Cholesterol esters in large VLDL particles maybe an important biomarker in the identification of early development of obesity associated T2DM risk among South Asian adults.

Source: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14788?af=R
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