Obesity markers in patients with drug allergy and body fat a
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Obesity is a chronic low-grade inflammation state associated with several diseases. This study aimed to investigate a potential link between drug allergy and obesity, exploring if the association depends on the type (immediate/non-immediate) and/or the severity of the reaction.

Anthropometric measurements, bioimpedance and biochemical analysis, including serum adipokines, were performed in 90 consecutive adult patients studied for suspected drug allergy. Logistic regression models were developed to identify predictors of drug allergy.

-- Eighty-four patients completed the diagnostic work-up (78.6% female; mean age 39.58±13.3 years).

-- Drug allergy was confirmed in 39 patients and excluded in 45 (controls).

-- Regarding BMI, 42.2% had normal weight and 55.3% were overweight/obese.

-- Fifty-eight percent of women and 41% of men presented criteria for central obesity.

-- Patients with drug allergy showed significantly higher BMI, waist and hip circumferences, waist-hip ratio, fat mass, body fat percentage (BFP), trunk fat mass, leptin levels and leptin-adiponectin ratio, than controls.

-- Similar results were obtained in the subgroup with immediate reactions, compared to the nonimmediate/unknown reactions.

-- The higher the BFP and the number of reactions, the greater the odds of drug allergy [(OR:1.07) and (OR:2.82], respectively.

-- An immediate reaction was also a predictor of drug allergy, compared with non-immediate/unknown reactions.

-- In patients with drug allergy, BFP was a predictor of having an immediate reaction.

Conclusively, this study shows, for the first time, evidence of a link between obesity and drug allergy, particularly immediate reactions. BFP emerged as a potential predictor of drug allergy.

Source: https://www.annallergy.org/article/S1081-1206(21)00215-5/fulltext?rss=yes