Obesity may drive HF risk in late-onset menopause
Postmenopausal women who are obese should be targeted with aggressive risk factor modification and close monitoring, particularly if they had experienced menopause at age 55 years or greater.

Researchers analyzed data from 4,441 women participating in the ARIC cohort study who had begun natural (n = 3,636) or surgical menopause (n = 808) by the fourth study visit (1996-1998). Researchers assessed BMI and waist circumference; prevalent HF at the fourth visit was determined from hospital discharge lists. Participants were stratified by menopausal age: younger than age 45 years (n = 1,200); age 45 to 49 years (n = 1,515); age 50 to 54 years (n = 1,468) and age 55 years and older (n = 258). Researchers estimated HRs for incident HF associated with menopausal age, testing for effect modification by obesity and adjusting for HF risk factors.

The attributable risk of generalized and central obesity for HF incidence was greatest among women who experienced menopause at age 55 years or older. Risk for incident HF for a 1 standard deviation increase in BMI was elevated in women with early menopause, menopause between ages 45 to 49 years, and late menopause. For every 6-inch increase in waist circumference, risk for developing HF almost tripled among women with late-onset menopause.

Source: https://www.healio.com/news/cardiology/20220413/obesity-may-drive-hf-risk-in-lateonset-menopause?utm_source=selligent&utm_medium=email&utm_campaign=news&M_BT=6562446793249