Obesity may drive HF risk in late-onset menopause
Researchers analyzed data from 4,441 women participating in the ARIC cohort study who had begun natural (n = 3,636) or surgical menopause (n = 808) by the fourth study visit (1996-1998). Researchers assessed BMI and waist circumference; prevalent HF at the fourth visit was determined from hospital discharge lists. Participants were stratified by menopausal age: younger than age 45 years (n = 1,200); age 45 to 49 years (n = 1,515); age 50 to 54 years (n = 1,468) and age 55 years and older (n = 258). Researchers estimated HRs for incident HF associated with menopausal age, testing for effect modification by obesity and adjusting for HF risk factors.

During 16.5 years of follow-up, researchers observed 903 incident HF events. The attributable risk of generalized and central obesity for HF incidence was greatest among women who experienced menopause at age 55 years or older, at 11.09 per 1,000 person-years and 7.38 per 1,000 person-years, respectively.

Risk for incident HF for a 1 standard deviation increase in BMI was elevated in women with early menopause (HR = 1.39; 95% CI, 1.05-1.84), those entering menopause at age 45 to 49 years (HR = 1.33; 95% CI, 1.06-1.67) and for those with late-onset menopause (HR = 2.02; 95% CI, 1.41-2.89). Higher BMI was not associated with increased HF risk among women who began menopause from age 50 to 54 years.

For every 6-inch increase in waist circumference, risk for developing HF almost tripled (HR = 2.93; 95% CI, 1.85-4.65) among women with late-onset menopause. Waist circumference did not raise HF risk for women in any of the other menopausal age groups.

Source: https://www.healio.com/news/cardiology/20220413/obesity-may-drive-hf-risk-in-lateonset-menopause