Obstructive sleep apnea-hypopnea syndrome may have predispos
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Patients with obstructive sleep apnea-hypopnea syndrome may experience damage to the meibomian glands and a shortened first noninvasive tear breakup time, which can lead to a predisposition for evaporative dry eye.

Researchers evaluated the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the meibomian glands, ocular surface and tear parameters in a prospective study of 59 individuals. The study included 32 participants with OSAHS and 27 control subjects.

All subjects underwent polysomnography, and Apnea Hypopnea Index value was recorded. Average noninvasive tear breakup time and first noninvasive tear breakup time were measured, and a Schirmer test was conducted. Researchers obtained meibography images, and impression cytology was performed with a sample from the superior temporal conjunctiva.

Seventeen participants had severe OSAHS, six had moderate OSAHS, and nine had mild OSAHS; 46.9% of these subjects had floppy eyelid syndrome compared with 7.4% in the control group. The median first noninvasive tear breakup time was 2.1 seconds in the study group and 5.7 seconds in the control group . The differences in average noninvasive tear breakup time and mean Schirmer value were not statistically significant.

The median value of loss in the meibomian glands in upper eyelid meibography was 20.1% in the study group compared with 14.7% in the control group. For lower eyelid meibography, the median value of loss was 19% in the study group compared with 12.4% in the control group. Using Spearman correlation analysis, a positive correlation was found between the severity of OSAHS and the upper eyelid meiboscore and total meibomian loss percentage. Additionally, a positive correlation was found in the OSAHS group between upper and lower meibomian gland loss rates.

Source: https://www.healio.com/news/ophthalmology/20200612/obstructive-sleep-apneahypopnea-syndrome-may-have-predisposition-for-evaporative-dry-eye
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