Open, laparoscopic-assisted, and robotic distal gastrectomy
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Laparoscopic-assisted distal gastrectomy and robotic distal gastrectomy for the treatment of early and locally advanced gastric cancer are effective.

The purpose of this study was to perform a comprehensive evaluation of major surgical approaches for operable distal gastric cancer.

A systematic review and network meta-analyses of randomized controlled trials were performed to compare open distal gastrectomy, laparoscopic-assisted distal gastrectomy, and robotic distal gastrectomy. Risk ratio, weighted mean difference, and 95% credible intervals were used as pooled effect size measures.

Seventeen randomized controlled trials (5,909 patients) were included. Overall, 2,776 underwent open distal gastrectomy, 2,964 laparoscopic-assisted distal gastrectomies, and 141 robotic distal gastrectomies.

--Among these 3 groups, there were no significant differences in 30-day mortality, anastomotic leak, and overall complications.

--Compared to open distal gastrectomy, laparoscopic-assisted distal gastrectomy was associated with significantly reduced intraoperative blood loss, early postoperative pain, time to first flatus, and hospital length of stay.

--Similarly, robotic distal gastrectomy was associated with significantly reduced blood loss and time to first flatus compared to open distal gastrectomy.

--No differences were found in the total number of harvested lymph nodes, tumor-free resection margins, 5-year overall, and disease-free survival.

--The subgroup analysis in locally advanced gastric cancer showed trends toward reduced blood loss, time to first flatus, and hospital length of stay with minimally invasive approaches but similar overall and disease-free survival.

In conclusion, laparoscopic-assisted distal gastrectomy and robotic distal gastrectomy performed by well-trained experienced surgeons, even in the setting of locally advanced gastric cancer, seem associated with improved short-term outcomes with similar overall and disease-free survival compared with open distal gastrectomy.

Surgery
Source: https://doi.org/10.1016/j.surg.2021.04.014
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