Ophthalmic corticosteroids in pregnant women with allergic c
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Highlights
• Corticosteroids in pregnancy were not associated with adverse neonatal outcomes.
• Neonatal outcomes include anomalies, preterm birth, and low birthweight.
• Fluorometholone 0.1% was most frequently used during the first trimester.

The risks of topical ophthalmic corticosteroids during pregnancy remain unclear. Researchers thus investigated the association between exposure to topical ophthalmic
corticosteroids during pregnancy and adverse neonatal outcomes.

Researchers identified 6847 eligible women of whom 898 (13%) had received topical ophthalmic corticosteroids. congenital anomalies occurred in 5.5% and 4.9%, preterm birth in 3.4% and 3.9%, LB in 5.9% and 7.0%, and the composite outcome in 11.7% and 11.7% of exposed and unexposed mothers, respectively. Corticosteroid eye drops were not significantly associated with an increase in congenital anomalies, low birthweight. The use of topical ophthalmic corticosteroids in pregnant women with allergic conjunctivitis was not associated with any increase in congenital anomalies, preterm birth, or low birthweight.

Source: https://www.ajo.com/article/S0002-9394(20)30362-7/pdf
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