Oral Ketorolac as an Adjuvant Agent for Postoperative Pain C
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Substantial post-operative pain is related with arthroscopic rotator cuff repair (RCR). Postoperatively, oral narcotics are the favorite analgesics. The effect of ketorols as a post-operative pain control supplementary drug following arthroscopic RCR is evaluated in this study.

Adult patients undergoing arthroscopic RCR were prospectively enrolled and randomized to one of two groups. The control received standard-of-care pain protocol, including oxycodone-acetaminophen 5 to 325 mg on discharge. The ketorolac group received the standard-of-care protocol, intravenous ketorolac at the completion of the procedure, and oral ketorolac on discharge.

Pain and functional outcome scores and narcotic utilization were recorded three times per day for the first 5 days after surgery. Repeat MRI was done at least 6 months postoperatively.

--39 patients were included for final analysis; the mean age of the cohort was 55.7 ± 10.6 years, and 66.7% of patients were male.

--No differences were observed in preoperative demographics, comorbidities, cuff tear morphology, and functional scores between the two groups.

--Over the first 5 days after surgery, patients in the ketorolac group consumed a mean of 10.6 fewer narcotic pills, a consumption reduction of 54.6%.

--No difference was observed in functional outcome scores at up to 6 weeks postoperatively between the two groups.

--No difference was observed in adverse events between the two groups with no reported cases of gastritis or gastrointestinal bleeding.

--22 of 39 patients underwent repeat magnetic resonance imaging at a mean of 7.9 months postoperatively, of which 5 demonstrated a retear of their rotator cuff.

--No significant difference was observed between the ketorolac and control groups in the rate of retear.

Adjunctive ketorolac substantially reduces narcotic utilization after arthroscopic RCR.

Source: https://journals.lww.com/jaaos/Abstract/9900/Oral_Ketorolac_as_an_Adjuvant_Agent_for.173.aspx