Oral and dental health status in patients undergoing neo-adj
A prospective, longitudinal assessment of oral and dental health status was done, from baseline until treatment completion, in patients scheduled to receive neoadjuvant chemotherapy (NACT) for locally advanced head and neck cancer (LAHNC).

150 consecutive, treatment-naïve adult patients with biopsy-proven LAHNC, scheduled to receive NACT, were recruited. 135 patients completed all assessments at 3 designated time points viz. baseline (T0), mid-treatment (T1), and post-treatment (T2). Variables assessed were: Oral Hygiene Index-Simplified (OHI-S), Decayed Missing Filled Teeth Index (DMFT), mucositis grade, pain score, and grade of trismus.

- Median OHI-S scores showed a statistically significant increase when the patients were evaluated from baseline to completion of NACT which indicated a decrease in oral health.

- There was no change in the median DMFT score but a significant change was seen in all-grade mucositis over time. Median pain scores and trismus grade decreased significantly over time.

There was a decrease in oral health status without any change in dental health seen in patients undergoing NACT. Mucositis was initially noted as an aftermath of chemotherapy which resolved with time.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
Source: https://doi.org/10.1016/j.oooo.2021.07.018