Oropharyngeal secretions may help cut false negative COVID-1
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Testing of oropharyngeal secretions (OS) may reduce the number of false-negative results from nasal swab testing of patients who have seemingly recovered from the disease, according to a study.

• In the study, published in the Journal of Dental Research, a small number of patients that had tested negative through nasopharyngeal swabs (NPS) were found to be positive through the testing of oropharyngeal secretions.

• It included 75 ready-for-discharge COVID-19 patients who tested negative using two consecutive nucleic acid amplification testing (NAAT) of viral samples retrieved with NPS, according to the researchers from Huazhong University of Science and Technology, China.

• Because of detection of potential false-negatives in that cohort, NAAT results of paired OS and NPS samples collected from 50 additional COVID-19 recruits during their recovery stage were used in a second prospective study to compare the diagnostic values of the two viral RNA sampling methods.

• Oropharyngeal secretions obtained from two of the 75 subjects in the first study yielded positive results for SARS-CoV-2 nucleic acid, the researchers said.

• In the second study, OS samples were significantly more sensitive for detection of the virus than NPS samples, and missed only 14 per cent of positive cases compared with 59 per cent for the NPS samples.

Source: https://www.eurekalert.org/pub_releases/2020-07/iaa-osm070220.php
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