Outcomes of Very Study finds, Preterm Infants Conceived with
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A Study was conducted to compare the mortality and early respiratory outcomes of very preterm infants conceived via assisted reproductive technology (ART) versus spontaneously.

Researchers identified inborn infants with gestational age (GA) less than 32 weeks (n=439); 54 cases were ART conceived. Spontaneously conceived controls (n=103) were matched by multiple gestation status and GA. Primary outcome was 1-year mortality.

Secondary outcomes were receipt of respiratory support and supplemental oxygen at 7 and 28 days and 36 weeks postmenstrual age (PMA). The association between conception method and outcomes by logistic regression, with adjustment for sociodemographic status was also evaluated.

Results:
--Women who conceived via ART had increased rates of pre-pregnancy and gestational diabetes, and no differences in rates of hypertensive disorders.

--Infant 1-year mortality was not different by mode of conception (ART 11.8% versus spontaneous 7.1%).

--Infants conceived by ART were less likely to receive respiratory support or supplemental oxygen at all time points, but this relationship only reached significance for receipt of oxygen at 28d (ART 20.8% versus spontaneous 39.0%); this remained true after adjustment for race/ethnicity and socioeconomic index.

In conclusion, when GA and multiple gestation status were controlled for, very preterm infants conceived after ART had comparable outcomes to those conceived spontaneously.

Source: https://www.jpeds.com/article/S0022-3476(21)00495-9/fulltext?rss=yes
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