Outcomes of islet transplantation in patients with type 1 di
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The study by the American Journal of Transplantation shows that ten-years outcomes of islet transplantation in patients having type 1 diabetes are effective in glycemic control.

The study describes the 10-year outcomes of islet transplantation within the Swiss-French GRAGIL Network, in patients with type 1 diabetes experiencing high glucose variability associated with severe hypoglycemia and/or with functional kidney graft.

Researchers conducted a retrospective analysis of all subjects transplanted in the GRAGIL-1c and GARGIL-2 islet transplantation trials and analyzed components of metabolic control, graft function, and safety outcomes over the 10-year period of follow-up. Forty-four patients were included. Thirty-one patients completed a ten-year follow-up.

--Ten years after islet transplantation, median HbA1c was 7.2% before transplantation. 17/23 recipients were free of severe hypoglycemia, 1/21 patient was insulin-independent, and median C-peptide was 0.6 ng/ml.

--Insulin requirements (UI/kg/day) were 0.3 vs 0.5 before transplantation. The Median [IQR] β-score was 1 and 51.9% of recipients had a functional islet graft at 10 years.

With a 10-year follow-up in a multicentric network, islet transplantation provided sustained improvement of glycemic control and was efficient to prevent severe hypoglycemia in almost 75% of the recipients.

Source: https://doi.org/10.1111/ajt.16637
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