Ovarian microcystic stromal tumor with significant bizarre n
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Ovarian microcystic stromal tumor is a relatively rare tumor type, which is characterized by morphology with microcyst structure, solid cellular areas, and hyalinized fibrous stroma. The most-reported tumors were stage I with a good prognosis. A 33-year-old woman was admitted because of an abdomen mass. B ultrasound examination of the abdomen and pelvis confirmed a right ovarian mass. The detection of tumor markers (CA125, HE4, CA199, and AFP) was normal. She had been pregnant once and did not give birth to a child. Her previous medical history and family history were unremarkable. The ovarian tumor was then resected laparoscopically.

Macroscopically, the tumor was well encapsulated, measured 3.2 × 3.0 × 2.6 cm. The cut surface of the mass revealed a tan-grayish appearance. Microscopically, the tumor mainly consisted of 3 fundamental components: microcysts, solid cellular zones, and fibrous stroma. The nests and islands of cellular areas were intersected by collagenous stroma with hyaline plaques. Microcysts structure predominated and this pattern was characterized by small rounded to oval cystic spaces. Intracytoplasmic vacuoles were also frequently present like “signet-ring” cell appearance. About 50% of tumor cells contained lightly eosinophilic to pale cytoplasm with a generally bland round to oval-shaped nuclei. However, obvious bizarre nuclei were present in about 50% of tumor cells. Mitosis was extremely rare (<1/50 high-power fields) in such areas.

Source: https://journals.lww.com/md-journal/Fulltext/2020/08210/Ovarian_microcystic_stromal_tumor_with_significant.85.aspx