Overlapping immunohistochemical features of adenocarcinoma o
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A retrospective case series. Three cases of adenocarcinoma of the NPCE were examined histologically with hematoxylin-eosin and immunohistochemical stains including vimentin, AE1/AE3, Cam 5.2, CK7, PAX2, PAX8, AMACR, and CAIX.

Researchers found that the immunohistochemical profile of adenocarcinoma of the NPCE can overlap with renal cell carcinoma. Both tumors can express vimentin, cytokeratin AE1/AE3, Cam 5.2, PAX2, PAX8, and AMACR. One of the adenocarcinomas of the NPCE in our series also expressed CD10 and the renal cell carcinoma marker (RCC Ma). Carbonic anhydrase IX (CAIX) was not detected in any of the three tumors.

Adenocarcinomas arising in phthisical eyes can be diagnostically challenging. It was found particularly difficult to distinguish adenocarcinoma of the NPCE from metastatic carcinoma, especially metastatic clear cell renal cell carcinoma and papillary renal cell carcinoma. Because of the immunophenotypic overlap, most patients will require systemic workup including imaging of the kidneys to be certain of the diagnosis.

Read more : https://www.sciencedirect.com/science/article/abs/pii/S0002939421000416?dgcid=rss_sd_all
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