Overweight and obesity in type 1 diabetes is not associated
Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensively studied. This study assessed the relationship between AG and UAG levels and body composition in patients with type 1 diabetes.

Researchers selected eighteen patients with type 1 diabetes and divided them into two groups: non-obese (BMI less than 25 kg/m2) and overweight (BMI more than 25 kg/m2). Demographics, parameters of body composition and serum parameters including AG and UAG, were assessed.

Results:
-- The patients with a BMI more than 25 kg/m2 were older and had a longer duration of diabetes.

-- AG and UAG levels were not significantly different between non-obese and overweight groups (mean AG non-obese±SD: 44.5±29.4 pg/ml and mean UAG non-obese 42.4±20.7 pg/ml vs mean AG overweight±SD: 46.1±29.6 pg/ml and mean UAG overweight 47.2±18.2 pg/ml).

-- AG/UAG ratios did not discriminate between these groups.

-- There was a positive association of insuline dose/kg bodyweight with BMI.

Conclusively, surprisingly, unlike non-diabetics and in T2D, we did not observe a difference in plasma levels of AG and UAG between normal weight and overweight adult type 1 diabetics. However, we did observe a positive correlation between BMI and insuline dose/kg bodyweight, suggesting that exogenous insulin is more important than the ghrelin system in the development of obesity in type 1 diabetes.

Source: https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-021-00699-4
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