Oxidative and antioxidative stress markers in keratoconus
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To conduct a systematic review and meta-analysis on the levels of oxidative stress markers and antioxidants in keratoconus compared to a healthy subject a study was conducted.

Researchers included 36 articles, for a total of 1328 keratoconus patients and 1208 healthy controls. There is an overall increase in oxidative stress markers in keratoconus compared with healthy controls, with a significant increase in reactive oxygen and nitrogen species and malondialdehyde. There is an overall decrease in antioxidants in keratoconus compared with healthy controls, with a significant decrease in total antioxidant capacity/status, aldehyde/NADPH dehydrogenase, lactoferrin/transferrin/albumin, and selenium/zinc. Oxidative stress markers were higher in tears and in the cornea of keratoconus than in aqueous humor, and antioxidants were decreased in tears, aqueous humour, and blood without difference between sample types. Oxidative stress markers increased in stromal cells and antioxidants decreased in the endothelium.

Oxidative stress markers and antioxidants were dysregulated in keratoconus, involving an imbalance of redox homeostasis in tears, cornea, aqueous humour, and blood.

Source:https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.14714?af=R
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