PCOS Features and Steroid Profiles Among Young Adult Women w
Premature adrenarche (PA) may increase the risk for polycystic ovary syndrome (PCOS). This study aimed to study features of PCOS in young adult women with a history of PA.

Thirty PA and forty-two control females were followed from prepuberty to young adulthood (median age 18.1 years). Ovarian function, the use of contraceptives, and clinical and biochemical indicators of hyperandrogenism were assessed.

Results:
Researchers found no differences in the use of hormonal contraceptives (50 vs 50%, PA vs controls, respectively), indication for using contraceptives, or in the history of oligo- (17 vs 26%) and amenorrhea (0 vs 0%).

-- Among women not using hormonal contraceptives, those with a history of PA had a higher prevalence of hirsutism (27 vs 0%) but not acne (87 vs 67%).

-- Steroid profiles were broadly comparable between the groups, but PA women had lower sex hormone-binding globulin (SHBG) concentrations (30.1 vs 62.4 nmol/l) resulting in higher free androgen index (3.94 vs 2.14).

-- The difference in SHBG levels persisted through BMI adjustment. SHBG correlated negatively with HOMA-IR.

-- Anti-Mullerian hormone concentrations were comparable between the groups (39.3 vs. 32.1 pmol/l).

Conclusively, PA was not associated with evident ovarian dysfunction in young adult women. However, women with a history of PA had decreased SHBG levels and thus, increased bioavailability of circulating androgens.

Source:
Like
Comment
Share