PCOS: Female Hair Loss & Gene Polymorphism
Recently a study was published in the Journal Of Formosan Medical Association, which was carried out with the aim to investigate whether women with polycystic ovary syndrome (PCOS) inheriting the Genetic variant of HSD3B1 124, exhibit specific androgenic phenotypes. HSD3B1 1245 is known to augment androgen production at peripheral tissue as skin.

According to the Rotterdam criteria of PCOS, the primary indicator of clinical hyperandrogenism is hirsutism and acne. Female pattern hair loss (FPHL), the female counterpart of male androgenetic alopecia, is not formally included in the diagnostic criteria, and has been a less studied presentation of PCOS. Increased serum concentrations of dihydrotestosterone (DHT) have been observed in female patients with FPHL, raising the possibility that disturbed metabolism of androgen might lead to FPHL in PCOS.

Significantly increased risks for extensive hair loss were observed in PCOS women with increased waist circumferences. On the other hand, patients with hyperandrogenism were also associated with increased frequency of obesity, hypertension and dyslipidemia.

The prevalence of FPHL among Taiwanese women with PCOS in this study was 14.6%. Compared with the higher prevalence of 20%–30% in US and India of similar-age women with PCOS, the results here suggest that an ethnic difference in the predisposition for FPHL development in PCOS patients might exist.

Hence, it was found that the presence of female pattern hair loss was higher in overweight women with polycystic ovary syndrome who comprised HSD3B1 AC or CC genotype compared with wild type.

Source: https://www.sciencedirect.com/science/article/pii/S0929664619302475
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