PRECISION Trials = Celecoxib to be as safe as naproxen and i
Full details of the trial are discussed here, but a few key findings from secondary analyses impact how we treat patients with OA and RA.

Key findings: Osteoarthritis
In patients with OA (mean age 63.5 years), celecoxib:

- Carries less CV risk than ibuprofen (HR = 0.84, 95% CI 0.72-0.98, P = 0.03) and similar risk to naproxen
- Has less gastrointestinal risk than ibuprofen (HR = 0.68, 95% CI 0.51-0.91, P = 0.01) and naproxen (HR 0.73 95% CI 0.55-0.98, P=0.04)
- Had fewer renal adverse events than ibuprofen and similar rates with naproxen (HR = 0.58, 95% CI 0.40-0.82, P = 0.003).
- Was similar to both ibuprofen and naproxen in all-cause mortality....

https://consultqd.clevelandclinic.org/2016/12/precision-results-precisely-tailored-arthritis-treatment/
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