Papillon–Lefèvre syndrome: a rare case of two brothers
Papillon–Lefèvre is an autosomal recessive syndrome that starts in early periods of childhood. Characteristic features include palmar plantar hyperkeratosis, aggressive periodontal disease, and a tendency for dry and chopped skin, thin and sparse hair.

The dental practitioner is often the first to diagnose the disease, as there is a significant degree of periodontal breakdown that is involved at an early age. This report, published in the International Journal of Clinical Pediatric Dentistry presents a clinical presentation of two brothers detected with Papillon–Lefèvre syndrome (PLS).

Case 1
A 12-year-old male reported with a complaint of mobile teeth for the last 6 months. According to the patient’s parents, his deciduous teeth erupted normally, but exfoliated at the age of 3. By the age of 10, the patient had multiple permanent teeth extracted due to mobility and now complains of mobility of the remaining permanent teeth.

Case 2
The second case was the younger brother of the first patient who is an 11-year-old male. The patient reported a similar chief complaint of mobile teeth and past dental history from his parents also discovered that his deciduous teeth erupted normally and exfoliated at the same age of his brother. On physical examination, bilateral hyperkeratotic lesions on the palm and soles were observed; however, no signs of keratosis were present on the knees and elbows.

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