Paracetamol can be used for patent ductus arteriosus closure
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The aim of this research was to present data on the use of intravenous (IV) and oral paracetamol to close PDA in preterm neonates born before 32 weeks of pregnancy (GA). Until now, indomethacin/ibuprofen, percutaneous transcatheter closure, or surgical ligation have been the traditional medical treatments for PDA closure.

Researchers conducted a prospective study in a neonatal intensive care unit (NICU). 87 preterm neonates born before 32-week GA with hemodynamically significant PDA (hsPDA) were enrolled. They received 15 mg/kg/6 h for 5 days IV or oral paracetamol for ductal closure. The study aims to vary the practice to use IV or oral paracetamol instead of ibuprofen to avoid side effects of nonsteroidal drugs in preterm babies.

Results:
--During the study period, 140 babies less than 32 weeks admitted to the NICU assessed for eligibility to the study, 87 of them received IV or oral paracetamol for the treatment of hsPDA for a total of 5 days.

--45 babies received IV paracetamol, while 42 received oral form with closure rate of 82.22% and 80.95%, respectively.

--Successful closure on paracetamol was achieved in 71 of 87 babies (81.6%).

In conclusion, Paracetamol is not only an alternative remedy for closing PDA, but it may also be the treatment of choice in the future.

Source: https://www.jcnonweb.com/article.asp?issn=2249-4847;year=2021;volume=10;issue=2;spage=79;epage=87;aulast=Mahmoud
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