Paraneoplastic limbic encephalitis in a patient with rectal
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Paraneoplastic neurological syndromes are defined as remote effects of cancer, not caused by the tumor and its metastasis, or by metabolic disruptions or ischemia. Paraneoplastic limbic encephalitis (PLE) is one of them, and commonly have been described in patients with lung or breast cancer. Colon and rectal cancers have also been shown to be associated with PLE as in our case. We report a case of 56-year-old male who had been diagnosed with adenocarcinoma of the rectum one year ago. He initially responded well to systemic chemotherapy, resulting in symptomatic relief related to the primary disease. However, one year after the initial diagnosis, the patient presented with recurrent seizures and disorientation for few days. Magnetic resonance imaging (MRI) scan of the brain was performed which demonstrated findings of PLE. Serum analysis revealed a high titer of anti-Ri, an antibody shown to be associated with paraneoplastic neurologic syndromes. The patient's symptoms improved markedly after treatment with antiepileptic therapy (phenobarbital) and methylprednisolone....

http://www.edoriumjournals.com/journal-of-case-reports-and-images-in-oncology/archive/2017-archive/100031Z10KH2017-hooda/100031Z10KH2017-hooda-full-text.php
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