Parathyroid hormone (PTH) analogues Efficacy on fracture hea
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The evidence for the use of parathyroid hormone (PTH) analogues to enhance fracture healing was tested by this meta-analysis. PTH enhanced functional results but did not affect the rate of fracture healing or alleviate pain.

The evidence of parathyroid hormone (PTH) analogues in fracture healing was analysed by this meta-analysis. The use of PTH analogues is well investigated for the prevention of osteoporotic fractures, and research on expanded indications are emerging. The impact of PTH in fracture healing is one such indication that receives growing attention; however, the overall degree of efficacy remains inconclusive.

A systematic electronic database search of MEDLINE, EMBASE and the Cochrane Library was conducted for relevant articles. Randomised controlled trials of adults with acute fractures treated with a PTH analogue were included. PTH was compared with a comparator intervention, placebo or no treatment.

Results:
--PTH analogue treatment improved functional outcomes in a range of fracture types but did not affect the fracture healing rate or reduce pain. Most trials included in this review were in elderly patients with osteoporosis. There was no evidence that PTH treatment caused harm or impeded fracture healing.

Conclusively, Meta-analysis supports the use of PTH analogues to improve functional outcomes but not fracture healing rate or pain for different fracture types. The evidence for PTH analogue use in fracture healing is less clear in younger, non-osteoporotic patient populations.

Source: https://link.springer.com/article/10.1007/s00198-021-05847-0
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