Parents' Autoimmune Diseases May Affect Children's Developme
The meta-analysis involved 14 studies that included 845,411 mothers and 601,148 fathers with an autoimmune disease and 4,984,965 control mothers and 4,992,854 control fathers. There were 182,927 children with neurodevelopmental disorders and 14,168,474 with no such diagnosis.

Globally, autoimmune diseases in mothers (adjusted odds ratio [AOR], 1.27 [1.03 – 1.57]; P = .02; I2 = 65%) and in fathers (AOR, 1.18 [1.07 – 1.30]; P = .01; I2 = 15.5%) are associated with a diagnosis of ASD in children. Similarly, they are associated with an increased risk of ADHD in children (AOR, 1.31 [1.11 – 1.55]; P = .001; I2 = 93% and AOR, 1.14 [1.10 – 1.17]; P < .0001; I2 = 0%, respectively, for mothers and fathers).

In mothers, type 1 diabetes (AOR, 1.60 [1.18 – 2.18]; P = .002; I2 = 0%), psoriasis (AOR, 1.45 [1.14 – 1.85]; P = .002; I2 = 0%), and rheumatoid arthritis (AOR, 1.38 [1.14 – 1.68]; P = .001; I2 = 0.8%) were associated with a risk of ASD in children. These three conditions also predisposed children to the risk of ADHD (AOR, 1.36 [1.24 – 1.52]; 1.41 [1.29 – 1.54]; and 1.32 [1.25 – 1.40], respectively, all P < .0001).

In fathers, type 1 diabetes considered in isolation was associated with a risk of ASD and ADHD in children (AOR, 1.42 [1.10 – 1.83] and 1.19 [1.08 – 1.31], respectively), while psoriasis (AOR, 1.18 [1.12 – 1.24]; P < .0001) is associated with a risk of ADHD in children.

Source: https://www.medscape.com/viewarticle/972960
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