Particulate matter from syringes used for intravitreal injec
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Syringes containing anti-VEGF drugs to treat retinal diseases are prepared in different ways by various parties with syringe selection, preparation, and storage conditions impacting the risk of injecting particles into the vitreous. This study examines particle loads from various syringes over time.

Four syringes were studied: two plastic transfer syringes lubricated with silicone oil or oleamide, a glass syringe with baked-on silicone, and a lubricant-free polymer syringe. Syringes were rinsed with water or filled with buffer and analyzed over time; particles were quantified by flow imaging. Particle formation in a bevacizumab formulation was also characterized.

Insulin syringes consistently showed very high particle counts. Oleamide-lubricated syringes had substantially fewer particles but showed appreciable increases over time (leading to visible particles). Baked-on silicone glass syringes and lubricant-free polymer syringes both showed low particle levels equal or more than 10 microns. Lubricant-free syringes showed the lowest particle levels equal or more than 1 micron and the lowest particle levels with bevacizumab agitation.

Syringes have different intrinsic particle loads which can contribute to particle loads in the delivered drug. Oleamide-lubricated transfer syringes, commonly used for bevacizumab repackaging, have time-dependent particle loads and are associated with the formation of visible particles beyond 30 days of storage.