Patent ductus arteriosus shunt elimination results in reduce
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A post hoc appraisal of the PDA RCT was conducted to assess the relationship between early patent ductus arteriosus (PDA) shunt elimination and chronic lung disease or death (CLD/Death).

Infants less than 29 weeks were divided into four groups:
--Intervention arm in whom PDA closure was achieved (n?=?17);
--Intervention arm in whom PDA closure was not achieved (n?=?13);
--Placebo arm (n?=?30);
--Low risk infants (n?=?13).
The main outcome measure was CLD/Death.

Results:
--The rates of CLD/Death were lower in the Intervention Success Group (29%) when compared to the Intervention Failure Group (85%) or the Placebo Group (60%).

--There was no difference in CLD/Death between the Intervention Success and Low Risk Groups (8%).

--A persistent PDA beyond Day 8 was associated with CLD/Death (aOR 6.5 [1.7–25.5]).

In conclusion, when compared to infants with prolonged shunt exposure, early shunt elimination in preterm infants with a PDA can reduce respiratory morbidity.

Source: https://www.nature.com/articles/s41372-021-01002-z
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