Patient-reported outcomes with Risankizumab versus fumaric a
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In a phase 3 clinical study, patients from Germany with moderate to severe psoriasis who were naive to systemic treatment and received risankizumab had greater and more rapid disease improvements compared with those who received fumaric acid esters (FAEs).

A Study was conducted to evaluate patient-reported outcomes (PROs) in patients treated with risankizumab compared with FAEs.

Adult patients were randomized 1:1 to receive either risankizumab 150 mg subcutaneous injections at Weeks 0, 4, and 16 or FAEs provided according to the prescribing label. PRO secondary endpoints assessed were Psoriasis Symptom Scale (PSS), Dermatology Life Quality Index (DLQI), 36-Item Short Form Health Survey, version 2 (SF-36v2), Patient Benefit Index (PBI), Hospital Anxiety and Depression Scale (HADS), Patient Global Assessment (PtGA), and European Quality of Life 5 Dimensions 5 Level (EQ-5D-5L). PROs were assessed at Weeks 0, 16, and 24.

Results:
60 patients each were randomized to receive risankizumab or FAEs.
-A significant PSS improvement was observed with risankizumab versus fumaric acid esters at Weeks 16 and 24 for total and psoriasis-associated redness, itching, and burning scores.
-DLQI scores were significantly lower (reflecting better health-related quality of life) with risankizumab versus fumaric acid esters, with least squares (LS) mean differences of -7.4 and -7.6 at Weeks 16 and 24, respectively.
-Patients randomized to risankizumab also had larger improvements in SF-36 Physical and Mental Component Summary scores, HADS anxiety and depression scores, PtGA, and EQ-5D-5L index and visual analog scale scores at Weeks 16 and 24 compared with fumaric acid esters.
-PBI was significantly higher, indicating greater benefit, with risankizumab versus fumaric acid esters, with an LS mean difference of 1.1 and 1.3 at Weeks 16 and 24, respectively.

In particular, Risankizumab provides significant benefits over fumaric acid esters in improving PROs across several dimensions in patients with moderate to severe psoriasis.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.17109?af=R
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