Patients Of COVID-19 With Psychiatric Illnesses At Higher Mo
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Psychiatric disorders are associated with shortened life expectancy. There is a concern that psychiatric comorbidity might increase COVID-19-related mortality, as suggested by prior preliminary studies of cardiac and infectious disease outcomes.

A large population study in Demark suggested that an a priori diagnosis of depression was associated with a higher 30-day mortality for those hospitalized for an infection. This study evaluated the association between having any prior psychiatric diagnosis and COVID-19-related mortality of hospitalized patients with COVID-19.

-- A total of 1685 patients were hospitalized with COVID-19 during the study period.
-- Of the 1685 patients, 473 received psychiatric diagnoses prior to hospitalization.
-- Patients with psychiatric diagnoses were significantly older and more likely to be female, white, and non-Hispanic and have medical comorbidities (malignant cancer, cerebrovascular disease, congestive heart failure, diabetes, kidney disease, liver disease, myocardial infarction, and/or HIV).
-- Overall, 318 patients died.
-- Patients with a psychiatric diagnosis had a higher mortality rate compared with those with no psychiatric diagnosis, with 35.7% vs 14.7% of 2-week mortality and 40.9% vs 22.2% of 3-week mortality rate and with 44.8% vs 31. 5% of 4-week mortality rate).
-- The median follow-up time was 8 days.
-- In the unadjusted model, the risk for COVID-19–related hospital death was greater for those with any psychiatric diagnosis.
-- After controlling for demographic characteristics, other medical comorbidities, and hospital location, the risk of death remained significantly greater among patients with a psychiatric disorder.

This is the first study, to the knowledge, that characterizes the association of psychiatric diagnosis with COVID-19–related mortality. The primary finding is that patients with a prior psychiatric diagnosis while hospitalized for COVID-19 had a higher mortality rate compared those without a psychiatric condition. The finding is similar to previous findings: individuals with concurrent psychiatric and medical diagnoses had poorer outcomes and higher mortality.