Patients with depression, hypertension in AS exhibit worse f
Patients with ankylosing spondylitis who exhibit depression and hypertension appear to demonstrate worse function and disease activity. The analysis included a total of 1,270 patients with AS, with an average symptom duration of 20.6 years. The most common characteristic was depression, present in 31.4% of patients. The second-most common, hypertension, was present in 26.1% of included patients. Meanwhile, uveitis was the most common extra-musculoskeletal manifestation, present in 30.4% of patients. The cluster indicating no comorbidities among included patients was “significantly younger, with lower symptom duration” (P < .001).

Additionally, female patients demonstrated a higher likelihood of being in the depression (OR = 2; 95% CI, 1.38-2.9) and uveitis (OR = 2.09; 95% CI, 1.41-3.11) groups, compared with clusters with no comorbidities. Comorbidity amounts and clusters with depression and hypertension were associated significantly with worse disease activity and functioning status.

Comorbidities are more common in ankylosing spondylitis compared to the general population, and they are associated with higher morbidity and mortality. However, different combinations of comorbidities with one another may have differential impacts on management of AS, as well as clinical outcomes.