Patterns Of Menstrual Cycle Length Can Predict Risk Of Heart
A study characterizes cycle length changes over the menopause transition and found that women whose cycle increased in length two years before their final menstrual period had better measures of vascular health than those who had stable cycle lengths during this transition. The researchers analyzed data from 428 participants enrolled in the ongoing study of Women’s Health Across the Nation and followed women aged 45 to 52 at time of enrollment for up to 10 years or until postmenopausal. The researchers collected menstrual cycle data throughout the menopause transition, and they assessed cardiovascular risk after menopause by measuring arterial stiffness or artery thickness. The researchers noted three distinct trajectories in menstrual cycle length during the menopause transition. About 62% of participants had stable cycles that didn't change appreciably before menopause, whereas about 16% and 22% experienced an early or late increase, defined as an increase in cycle length five years or two years before their final menstrual period, respectively. Results showed that women with the late-increase pattern had significantly lower postmenopausal cIMT (0.72 mm) and baPWV (1392 cm/s) levels than the stable group (0.77 mm and 1508 cm/s, respectively) adjusting for race, concurrent age, socioeconomic status, physical activity level, and premenopausal cardiovascular risk profile. Splines revealed a nonlinear trajectory of VAT with two inflection points demarcating three time segments: segment 1: >2 years before FMP; segment 2: 2 years before FMP to FMP; and segment 3: after FMP. It was concluded that patterns of cycle length over the MT seem to be a marker of future vascular health that may help identify groups at greater or lesser risk of atherosclerosis after menopause.

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https://journals.lww.com/menopausejournal/Abstract/9000/Patterns_of_menstrual_cycle_length_over_the.96884.aspx
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