People with and without Alzheimer’s Disease have a different
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The risk of both mortality and rehospitalization after an elective revascularization procedure for coronary artery disease is similar for people with and without Alzheimer's disease (AD), but people with AD had worse outcomes after an emergency procedure, according to a new study.

The Medication Use and Alzheimer’s disease (MEDALZ) cohort includes 70718 community dwellers diagnosed with incident AD. For each person with AD, 1–4 age-, sex-, and hospital district-matched comparison persons without AD were identified. Altogether 448 persons with AD and 5909 without AD underwent revascularization during the follow-up. The outcomes were 30-day and 90-day re-admission rate after discharge, and all-cause 1-year and 3-year mortality.

--People with AD had less revascularizations. Emergency procedures were more common than elective procedures among people with AD.

--There was no difference in 30-day readmissions or 1-year mortality and 90 days readmission risk was lower in persons with AD.

--People with AD had higher 3-year mortality, but the risk increase was observed only for emergency, not for elective procedures.

Conclusively, people with AD did not have worse readmission and mortality outcomes following elective revascularization. These findings in conjunction with lower revascularization rate especially for elective procedures raise questions on the threshold for elective procedures in people with AD.

The Journals of Gerontology