Perineural Spread of Head and Neck Cancer: Ophthalmic Consid
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Head and neck malignancies with orbital involvement present difficult decisions to the treating physician. When the spread is perineural, the challenges are greater due to the incipient nature of the spread and the fact that the orbit can also be involved by centrifugal spread from the non-ophthalmic branches of the trigeminal nerve. The disease is often misdiagnosed and the subsequent delay in treatment results in worse outcomes. This article discusses the evaluation of the eye and the many facets of orbital involvement by the perineural spread of malignancy including the treatment of complications.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846412/
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