Pituicytoma associated with serum Adrenocorticotropic hormon
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Pituicytoma is a rare benign tumour of the neurohypophysis or hypophyseal stalk. Endocrinological abnormalities derived from this tumour are even rarer. Although three cases of pituicytoma with elevated plasma adrenocorticotropic hormone (ACTH) have been reported previously, the etiological mechanisms remain unknown. Case Description: We present a 47-year-old woman who was referred to a hospital complaining of a headache. On investigation using magnetic resonance imaging (MRI), a tumour was detected in the sellar region. Elevation of basal ACTH and serum cortisol was identified, suggesting an ACTH-producing pituitary adenoma. However, physical findings and results of other hormonal examination showed no evidence of Cushing disease. The tumour had been detected incidentally eight years earlier when MRI was performed and showed considerable enlargement on this consultation. Endoscopic endonasal transsphenoidal surgery was performed in order to remove the tumour completely. The histopathological diagnosis was pituicytoma. The patient’s postoperative clinical course was excellent, and both ACTH and cortisol levels returned to normal following surgery. Conclusions: It appears that ACTH was being secreted from the tumour cells. We discuss the possible mechanism of ACTH elevation in cases of pituicytoma.

https://goo.gl/QQ0zKx
Like
Comment
Share