Placental morphology and the prediction of underlying Cardio
Pre-eclampsia is associated with an increased risk of future cardiovascular disease. Maladaptive vascularization in preeclamptic placentas linked to endothelial dysfunction. Placental morphology measurements may be a marker of future maternal cardiovascular disease risk.

The purpose of this study was to investigate the relationship between placental size and cardiovascular risk when assessed at six months postpartum in women who experienced pre-eclampsia.

Maternal clinical and biochemical cardiovascular risk factors were used to categorize preeclamptic women into high vs. low lifetime cardiovascular disease risk profiles at six months postpartum. A multivariable logistic regression model was then used to identify the association between placental weight to birth weight ratio and high lifetime cardiovascular disease risk, adjusting for maternal age, pre-pregnancy BMI, and severity of pre-eclampsia. 186/216 women with pre-eclampsia met inclusion criteria.

--No significant differences were observed for placental morphometric measurements between women who screened as having a high vs. low lifetime risk profile for cardiovascular disease at six months postpartum.

--However, using multivariable modeling that controlled for maternal age, pre-pregnancy BMI, gestational age at delivery, and severity of pre-eclampsia, a low placenta to birth weight ratio was associated with an increased odds of high lifetime cardiovascular disease risk.

The findings of the current study identify clinical measurements that can be collected at the time of delivery which may help identify specific women who may benefit most from postpartum cardiovascular risk screening and intervention.

European Journal of Obstetrics & Gynecology and Reproductive Biology