Platelet-rich fibrin in preventing hemorrhagic complications
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The number of anticoagulated patients requiring dental extractions and other minor dentoalveolar surgical procedures has increased significantly. This study shows that platelet-rich fibrin (PRF) does not prevent hemorrhagic complications.

The purpose of this study was to determine whether the use of platelet-rich fibrin (PRF) prevents hemorrhagic complications after dental extractions in patients being treated with oral anticoagulants.

Searches were conducted through Medline via PubMed, Web of Science, LILACS, Central Cochrane, Scopus, DOSS, and Google Scholar. The predictor variable was the study group (PRF versus use/non-use of other hemostatic agents). The main outcome of interest was the risk of bleeding after tooth extraction and the covariates were postoperative complications. From a total of 216 articles, 3 articles were included for evaluation in this systematic review and meta-analysis. A total of 130 patients were involved.

- The outcomes of the meta-analysis showed that the use of PRF in extraction wounds did not reduce the risk of bleeding after extraction in anticoagulated patients.

- Furthermore, the use of PRF did not improve pain scores or the risk of postoperative alveolitis in anticoagulated patients. The certainty of the evidence ranged from moderate to low.

The findings of this systematic review and meta-analysis suggest that PRF does not prevent hemorrhagic complications after tooth extraction in patients using oral anticoagulant therapy.
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