Platelet-rich plasma shows limited efficacy in hair growth r
While platelet-rich plasma failed to yield improvements over placebo in alopecia areata as assessed by Severity of Alopecia Tool score, some parameters of immune response did improve with treatment, according to a study.

Platelet-rich plasma has shown some promise in the treatment of alopecia areata. This study aimed to evaluate the effect of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata.

This was a randomized, placebo-controlled, split-head study involving 27 patients with alopecia areata (Severity of Alopecia Tool score more than 25%). Alopecia patches on either side of the scalp were randomized to receive 3 intradermal injections of platelet-rich plasma or normal saline at monthly intervals and evaluated 3 months after the last session. Lesional T-cell cytokine messenger RNA expression was compared pre- and posttreatment in the platelet-rich plasma–treated sites.

Results:
-- The mean Severity of Alopecia Tool score did not change significantly compared with baseline with either platelet-rich plasma or placebo injections at any visit; however, the mean percentage reduction in the score in the platelet-rich plasma arm was more than in the placebo arm (9.05% ± 36.48% vs 4.99% ± 33.88%) at final assessment.

-- The mean interferon gamma (P = .001) and interleukin 17 cytokine messenger RNA expression decreased, whereas the mean interleukin 10 and FOXP3 messenger RNA expression increased significantly after platelet-rich plasma treatment.

Conclusively, platelet-rich plasma was found to have limited efficacy in alopecia areata. However, it may play a role in restoring immune balance in the alopecic patches.

Source: https://www.jaad.org/article/S0190-9622(20)33231-X/fulltext
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