Pleomorphic adenoma mimicking oral malignancy: a challenge f
The present case has bee reported in the journal Contemporary Clinical Dentistry.

A 50-year-old man presented with a mass in the right retromolar region that had been slowly enlarging over the previous 2 years with no pain. Physical examination revealed a firm mass measuring 1 cm × 1 cm. A provisional diagnosis of benign tumor of salivary gland or mucocele was made. Complete mass excision was done.

Grossly tumor was well-encapsulated, grayish-white, and measured 2 cm × 1 cm × 1.5 cm. The cut surface showed no cystic area, hemorrhage or necrosis. The specimen was submitted for routine microscopic examination.

Histological features showed an encapsulated tumor mass with approximately 70% of the tumor volume composed of superficial and deep-seated keratin-filled multicystic spaces of variable size and shape, lined by metaplastic squamous epithelium.

The epithelial component of the tumor showed solid sheets, nests of ductal structures. No dysplastic features or mitotic figures were evident within the squamous cells. Occasional foci of residual chondromyxoid matrix were seen. These microscopic features were suggestive of PA with extensive squamous metaplasia.

Key takeaways:-
- To prevent the misdiagnosis of PA with exuberant squamous metaplasia as a malignancy, cautious and systematic approach in the histopathologic interpretation of the epithelial and connective tissue component is needed.

- It is important to be aware of this possibility to distinguish it from malignant lesions and to avoid unnecessarily aggressive therapy.

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