Pollution exposure, preexisting asthma or COPD may raise odd
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Among patients with COVID-19 and preexisting asthma or COPD, long-term exposure to air pollution was associated with higher odds for hospitalization, according to results of a pilot study published in Respiratory Medicine.

Ecological evidence suggests that exposure to air pollution affects COVID-19 outcomes. However, no individual-level study has confirmed the association to date.

Researchers identified COVID-19 patients diagnosed at the University of Cincinnati hospitals and clinics and estimated particulate matter less than 2.5 µm (PM2.5) exposure over a 10-year period at their residential zip codes. They used logistic regression to evaluate the association between PM2.5 exposure and hospitalizations for COVID-19, adjusting for socioeconomic characteristics and comorbidities.

Results:
-- Among the 1128 patients included in our study, the mean (standard deviation) PM2.5 was 11.34 (0.70) µg/m3 for the 10-year average exposure and 13.83 (1.03) µg/m3 for the 10-year maximal exposures.

-- The association between long-term PM2.5 exposure and hospitalization for COVID-19 was contingent upon having pre-existing asthma or chronic obstructive pulmonary (COPD).

-- In COVID-19 patients with asthma or COPD, the odds of hospitalization were 62% higher with 1 µg/m3 increment in 10-year average PM2.5 and 65% higher with 1 µg/m3 increase in 10-year maximal PM2.5 levels.

-- However, among COVID-19 patients without asthma or COPD, PM2.5 exposure was not associated with higher hospitalizations.

Conclusively, long-term exposure to PM2.5 is associated with higher odds of hospitalization in COVID-19 patients with pre-existing asthma or COPD.

Source: https://www.resmedjournal.com/article/S0954-6111(21)00019-6/fulltext
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