Porokeratosis and malignant potential
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Porokeratosis (PK) is a rare group of keratinization disorders. While the overall prognosis of PK is favorable, malignant transformation of PK to skin cancer has been reported in 6.9% to 11.6% of the cases

A single-center retrospective chart review of patients with a diagnosis of PK was conducted.

In this study, 6.4% to 16.4% of histologically confirmed PK lesions demonstrated malignant transformation. A higher proportion of disseminated superficial actinic porokeratosis (DSAP) cases (as high as 29.3%) showed malignant transformation compared to PK of Mibelli (as high as 6.0%).

Out of the two cases of linear PK, both demonstrated malignant transformation.

In summary, PKs are at risk for malignant transformation, and patients with DSAP and linear PK, in particular, should receive more long-term surveillance. Limitations of this study include the inability to control for confounding factors due to the retrospective nature and the small size of cohort.

Source: https://www.cureus.com/articles/50985-the-malignancy-potential-of-porokeratosis-a-single-center-retrospective-study
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