Possible anti-inflammatory effects of the specific carbohydr
A Study was conducted to explore the possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. This diet has shown anti-inflammatory effect in children with inflammatory bowel disease.

This exploratory investigation was complete with 22 patients (age 6.3–17.3 years) with young idiopathic arthritis, less than 2 inflamed joints, with a sedimentation rate of erythrocyte of less than 30 mm/h. 15 youngsters were assessed with 4 weeks of diet. Parents and children were introduced to the diet by a dietitian and 2 follow-ups were carried out through the procedure. The assays and multiplexes of 92 inflammatory proteins have been employed in conventional labs. Faecal samples were analyzed for short-chain fatty acids.

Results:
--The diet significantly decreased morning stiffness and pain.

--Physical function, assessed through the child health assessment questionnaire, improved.

--Arthritis improved in 5 of the 7 children with arthritis; in those 7, multiplex analysis showed a significant decrease in 9 inflammatory proteins, including TNF-alpha, after 4 weeks. Faecal butyrate, analysed in all 15 participants, increased significantly.

Conclusively, the specific carbohydrate diet may have significant positive effects on arthritis in children with juvenile idiopathic arthritis.

Source: https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-021-00577-3
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