Post-PCI Diastolic Pressure Ratio May Predict Risk Of Advers
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An increasing body of evidence supports the use of either fractional flow reserve (FFR) or the non-hyperaemic instantaneous wave-free ratio (iFR) for intracoronary physiological assessment of intermediate coronary artery lesions.

The dPR SEARCH study is a post hoc analysis of the prospective single-centre FFR-SEARCH registry, in which physiological assessment was performed after angiographically successful PCI in a total of 1000 patients between March 2016 and May 2017. They further calculated dRP offline with recently validated software in a subset of 735 patients.

Upon analysis, the researchers observed that the mean post-PCI dPR was 0.95±0.06. Post-PCI dPR was 0.89 in 15.2% of the patients. The cumulative incidence of TVF at 2 year follow-up was 9.4% in patients with a final post-PCI dPR 0.89 as compared to 6.1% in patients with a post-PCI dPR >0.89 (adjusted hazard ratio [HR] for dPR 0.89: 1.53). Post-PCI dPR of 0.89, which was associated with a higher cardiac mortality at 2 years; adjusted HR 2.40.

Source: https://link.springer.com/article/10.1007/s12471-022-01680-0
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