Postexercise troponin I levels in patients with suspected st
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Previous studies showed that troponin blood levels may increase after exercise. In this study, we assessed whether, among patients with suspected of having stable angina, the increase in troponin I (TnI) levels after exercise stress test (EST) might help identify those with obstructive coronary artery disease (CAD) and myocardial ischemia.

Researchers performed maximal treadmill EST in 50 patients (age 64 ± 9 years; 38 men) to undergo elective coronary angiography because of a suspicion of stable angina. TnI was measured before and 12 h after EST.

-- TnI increased after EST compared with baseline in the whole population (from 0.44 ± 0.76 to 0.84 ± 1.12 ng/dl).

-- No difference in TnI increase was observed between patients with obstructive CAD and no obstructive CAD.

-- There was also no significant difference in post-EST TnI increase between patients with positive EST or negative EST.

-- Moreover, no significant difference was observed in the post-EST TnI increase among groups of patients with positive EST and obstructive CAD, positive EST and NO-CAD, negative EST and obstructive CAD and negative EST and NO-CAD.

-- No clinical or EST variable was associated with post-EST TnI increase, although there was a tendency for a greater increase in those achieving a heart rate more than 85 vs. less than 85% of maximal predicted heart rate during EST.

Conclusively, TnI increase after EST in patients with suspected stable angina is largely independent of the results of coronary angiography and EST.