Potential value of circulating endothelial cells for the dia
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The ongoing SARS-CoV-2 pandemic has been a formidable global challenge. As yet, there are very few drugs to treat this infection and no vaccine is currently available. Authors have gradually come to realize that COVID-19 is not a simple disease involving a single organ; rather, many vital organs and systems are affected.

The endothelium is also a target of SARS-CoV-2. Damaged endothelial cells, which break away from organs and enter the blood to form circulating endothelial cells, were recently reported as putative biomarkers for COVID-19.

Additionally, by modulating the expression level of sphingosine-1 phosphate via sphingosine kinase activation, endothelial cell proliferation and apoptosis can be controlled.

Thus, it may be possible to obtain a sensitive and specific diagnosis of COVID-19 severity by assessing the absolute number and the viable/apoptotic ratio of circulating endothelial cells.

Furthermore, a focus on the endothelium could help to develop a strategy for COVID-19 treatment from the perspective of endothelium protection and repair.

Source: https://www.ijidonline.com/article/S1201-9712(21)00402-1/fulltext?rss=yes
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