Predictive value of coagulation profiles for both initial an
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Intravenous immunoglobulin (IVIG) resistance prediction remains substantial in Kawasaki disease (KD), with limited data on the predictive value of coagulation profile for IVIG resistance, particularly for repeated IVIG resistance. Therefore, the aim of this study was to testify the predictive validity of coagulation profile for both initial and repeated IVIG resistance in KD.

A total of 385 KD patients were prospectively recruited. Coagulation and other profiles were evaluated between IVIG responsive and IVIG resistant groups. Multivariate logistic regression analysis was applied to determine the association between coagulation profiles and IVIG resistance. ROC curves analysis was further performed to assess validity of coagulation profiles in predicting both initial and repeated IVIG resistance.

Results:
--Prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), fibrinogen degradation products (FDP) and D-dimer were significantly increased in initial IVIG resistant group with antithrombin III (ATIII) and thrombin time (TT) significantly reduced.

--Meanwhile, ATIII was declined markedly in repeated IVIG-resistant patients.

--Multivariate logistic regression analysis showed that PT, APTT, D-dimer and ATIII were independent risk factors for predicting initial IVIG resistance, and ATIII for predicting repeated IVIG resistant patients with KD.

--PT, APTT, D-dimer and ATIII cutoff values of 13.95 s, 41.15 s, 1.48 mg/l, and 89.5% yielded sensitivities of 73%, 32%, 71%, 81%; specificities of 55%, 88%, 62%, 51% for predicting initial IVIG resistance, respectively.

--The cutoff value of ATIII for predicting repeated IVIG resistance was 68.5%, with sensitivity of 71% and specificity of 55%.

In conclusion, KD patients who experience hypercoagulation during the acute phase may be more likely to develop IVIG resistance.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13495https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13495
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