Predictors for the development of Tracheobronchomalacia in P
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Tracheobronchomalacia (TBM) contributes to the increased morbidity and mortality observed in preterm infants. Effective strategies for the prevention of TBM are necessary to achieve better outcomes. Researchers sought to identify risk factors associated with the development of TBM in preterm infants. Optimal cut-off values for each risk factor were also determined.

The study sample consisted of 80 infants who were delivered at 36 weeks of pregnancy or earlier and had flexible bronchoscopy. Multivariate logistic regression analysis was used to compare demographic and clinical risk factors between those with TBM (n = 35) and those without TBM (n = 45). The optimal cut-off values for forecasting the development of TBM were determined using receiver operating characteristic curve analysis.

Results:
--In the multivariate analysis, only peak inspiratory pressure (PIP) and the number of intubation days remained significantly different between infants with and without TBM.

--Preterm infants with TBM received higher PIP and were intubated for longer than those without TBM.

--Infants who received PIP more than 19.5 cmH2O or were intubated for more than 79.5 days were associated with a significantly higher risk of presence of TBM.

High PIP and extended intubation, in particular, were significant risk factors for the development of TBM in preterm newborns. Bronchoscopy evaluation is recommended for those who require PIP greater than 19.5 cmH2O or intubation for more than 79.5 days for early detection and therapy of TBM.

Source: https://onlinelibrary.wiley.com/doi/10.1002/ppul.25445?af=R
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