Predictors of the age at which natural menopause occurs in w
Women with type 1 diabetes (T1D) are to experience menopause earlier than women without diabetes. The study was published in Menopause.

Researchers assessed metabolic predictors of the age at which natural menopause occurs among women with T1D participating in the Epidemiology of Diabetes Complications Study.

Women with childhood-onset of T1D who underwent natural menopause without the use of hormone therapy during their menopausal transition were included in the analysis. Self-reported reproductive history and the Women's Ischemia Syndrome Evaluation hormonal algorithms were used to determine menopause status. Linear regression was used to ascertain whether time-weighted metabolic factors (eg, BMI, lipids, HbA1c, insulin dose, albumin excretion rate [AER]) were associated with age at natural menopause.

- Univariately, only insulin dose and log (AER) were associated (negatively) with age at natural menopause.

- Adjusting for BMI, smoking status, lipids, HbA1c, number of pregnancies, and oral contraceptive use, each 0.1 unit increase in the daily dose of insulin per kilogram body weight was associated with 0.64 years younger age at natural menopause, while for every 30% increase in AER, age at natural menopause decreased by 0.18 years.

Conclusively, higher average levels of insulin dose and AER over time were significantly associated with a younger age at which natural menopause occurred among women with T1D.